This paper introduces an integrated Hardware-In-the-Loop (HIL) testing framework, combining the UVA/Padova Type 1 Diabetes Simulator with AndroidAPS, an open-source artificial pancreas system. This integration forms a testing environment capable of evaluating insulin regulation algorithms under both virtual and real hardware conditions. The FDA-approved UVA / Padova Simulator models glucose-insulin dynamics and meal digestion. Paired with AndroidAPS, the system can actuate real-world insulin pumps to test insulin delivery control algorithms. The framework is tied together by various REST APIs and uses the Flask framework for efficient data exchange and system connectivity. The HIL approach provides a robust platform for functional and reliability testing of these algorithms. The developed APIs are open-source: https://github.com/OE-Diab/AP-HIL